It is well known that ACTH/MSH-like peptides

(melanocortins) exert pleiotropic non-hormonal

actions among their larger activities.

Melanocortins affect learning processes and

exploratory behavior, regeneration and

development, nociceptive and inflammatory

processes, accelerate nerve regeneration and

improve neuromuscular performance. Together

these classes of peptides control many behaviors

such as regulating attention, processes of

learning, and memory formation as a result of

their pronounced effect on CNS functions.

Heptapeptide SEMAX (MEHFPGP) is the

analogue of ACTH (4-10) that has prolonged

neurotropic activity and thus is a good candidate

for medical therapy. Currently this peptide is

successfully used in treatment of patients with

pathologies related to brain circulation

dysfunction and with different intellectualamnestic problems of the CNS. Doctors have

prescribed it for many conditions like anxiety,

memory improvement, ischemic events, stroke,

nerve regeneration, ADHD, opioid withdrawal,

and even chronic diseases such as ALS,

Parkinson’s, and Alzheimer’s. Some doctors use

it as a preventative measure to protect against

chronic disease and to acutely help improve

memory and learning processes. It also has a

marked antithrombotic and fibrinolytic effect and

a gastric protective effect. It has also been

suggested in literature that due to its effect on

carboxypeptidase it can also increase physical

performance and adaptation capacities in

exposure to high intensity exercise. At its higher

doses, .5mg/kg can even be analgesic.

Often prescribed for: Anti-Thrombosis, ADHD/

Learning, Gastric protection, Physical exertion

improvement pain, Metal toxicities.