This cream contains a Bi-Est or Bi-Estrogen component, which consists of two estrogens – Estradiol and Estriol. There are three types of estrogen that are produced by the ovaries: Estrone (E1), Estradiol (E2), and Estriol (E3). Estradiol is the dominant estrogen in premenopausal women. Estrone is the second dominant estrogen and is produced by the metabolism of estradiol. Estriol is the weakest of the three estrogens but it is considered the safest estrogen.
Progesterone is added to estrogen therapy to prevent the overgrowth of the cells that line the uterus, which can lead to uterine cancer. Therefore, women who have not had a hysterectomy (removal of the uterus) will receive progesterone in addition to estrogen.
Low levels of estrogen can result in symptoms such as irregular menstrual periods, sleep disturbances, excessive sweating, and vaginal dryness. Over time, low levels of estrogen can lead to complications such as osteoporosis, depression and heart disease. If you have low estrogen levels and are experiencing symptoms, your doctor may choose to prescribe bioidentical hormone replacement therapy.
